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The City of Cottleville in St. Charles County was named the safest city in Missouri by SafeWise.com for the third consecutive year.

Two Other St. Charles County Cities are Included in the 2024 Ranking - O'Fallon (#12) and Lake Saint Louis (#19).

St. Charles City Centre Complex

Chamber Endorsed Prop C Passes

The $85 million Proposition C is a NO TAX INCREASE BOND ISSUE that will finance the entire CITY CENTRE COMPLEX. That’s not just City Hall, it will include things such as: the Historical Society, a Senior Center with a Rec Center component, Sister Cities International offices, an Arts & Cultural center with restaurant incubators, and much, much more.

St. Charles Community College Groundbreaking

St. Charles Community College breaks ground on Regional Workforce Innovation Center

Expected to open in Summer 2025, the Regional Workforce Innovation Center is the first building on the Community College's new 55-acre Wentzville Campus near David Hoekel Parkway.

St. Charles County Leads Region in Large Municipality Growth

According to recent US Census Data, St. Charles County is home to the four fastest-growing large municipalities in the St. Louis metro area. From 2020 - 2022, Wentzville was the region's growth leader, posting a 6% population increase, followed by O’Fallon, St. Peters, and the City of St. Charles.

St. Peters MO

St. Peters Named #22 Best Place To Live

Money Magazine has named the City of St. Peters to its 2021 list of the Best Places to Live in America. St. Peters was the only Missouri city named to the 2021 list.

Katy Trail

Katy Trail State Park has been named the #2 Recreational Trail in the nation in USA Today’s 10 Best Readers’ Choice Awards

Did you know the trailhead for the Katy Trail is in St. Charles County? The portion running through St. Charles County is also some of the most used portion of the trail.  Read more about this year's rankings.

Best Place To Start A Business

St. Charles County Among The Best Places To Start A Business

WalletHub recently released it list of best and worst places to start a business and four St. Charles County (Wentzville, St. Charles, St. Peters, and O'Fallon) rank among the Top 500 of best places to start a business!  More than 1,300 cites were evaluated on their business-friendliness.

Welcome to the St. Charles Regional Chamber

Welcome to the home page of the St. Charles Regional Chamber! We're glad you're here!

Our Mission: We advocate for our business community by developing opportunities and partnerships that strengthen the economic prosperity and sustainability of our region.

Mark Your Calendar

Available Now......Free Basic Memberships!

We are thrilled to unveil a groundbreaking initiative designed to foster greater connectivity and support for our vibrant business community—the St. Charles Regional Chamber's Free Basic Membership!

This innovative membership tier opens doors for businesses of all sizes to join our dynamic network without any financial commitment. Embracing inclusivity and community growth, the Free Basic Membership provides access to essential resources, networking opportunities, and a platform to showcase your business within our thriving ecosystem.

Join us in shaping the future of the St. Charles County business landscape! Whether you're a startup or an established enterprise, your success is our priority.

Win A Trip For Two To Ireland!

Travel to Italy's Amalfi Coast with the Chamber!

Almalfi Coast Ad

The St. Charles Regional Chamber is thrilled to invite you on an unforgettable journey to one of the most beautiful destinations in the world – the Amalfi Coast!

From March 3-10, 2025, immerse yourself in the stunning landscapes, rich history, and vibrant culture of Italy. 🇮🇹✨

This is more than a vacation; it's an adventure filled with culture, cuisine, and camaraderie. Don't miss this incredible opportunity to explore, connect, and create lasting memories with your fellow community members.

Reserve your spot today! For more details and to sign up, visit our website or contact the St. Charles Regional Chamber office.

Pack your bags, bring your sense of wonder, and get ready for an extraordinary Italian escape! 🌟✈️

2024 Sip & Savor - 25th Anniversary

Tickets On Sale Now!!

Regular ticket sales open May 30

May 30 - Ticket Price is $40

September 1 - Ticket Price is $45

Purchase your tickets

Shop Local

ShopSt.C Digital Gift Card 

We are pleased to announce the new ShopSt.C Digital Gift Card, an e-card that makes it fun and easy to keep local spending local.

Sponsored by Mastercard

We are currently signing up local businesses to participate in the program.

Read More

Purchase a Card or Sign Up Your Business (scroll to bottom)

Local Information

Community Resource Guide

The Chamber's Community Resource Guide provides information on St. Charles County and is great for anyone looking to relocate or open a business here. Click on the link below to view online or call 636.946.0633 to have one mailed.

Community Resource Guide

Chamber Benefit Plan

The Chamber Benefit Plan is a self-funded medical offering built on the multiple employer welfare arrangement model. This program enables smaller employers to join together to share in the overall claims risk.

Powered by the Missouri Chamber Federation and administered by Anthem Blue Cross and Blue Shield, the Chamber Benefit Plan is available to small group employers in Missouri who have 2 to 50 eligible employees.

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